Radio-isotope investigations in primary myeloid metaplasia.
نویسنده
چکیده
Chromium-51 and iron-59 studies in patients with primary myeloid metaplasia show that the anaemia of the condition is dependent on depression of marrow activity, aggravated in about one-third of cases by accelerated red cell destruction to which the marrow compensatory response is inadequate. Surface measurements of isotope activity assist in assessing dependence on extramedullary sites for erythropoiesis and in diagnosis. The relevance of these findings to the hypotheses of the pathogenesis of the condition is discussed.
منابع مشابه
Increased circulating CSF-1 (M-CSF) in myeloproliferative disease: association with myeloid metaplasia and peripheral bone marrow extension.
Myeloproliferative disease (MPD) is heterogeneous in phenotypic expression and may display features consistent with expansion and activation of the monocyte/macrophage population during its course. The role of colony-stimulating factor-1 (CSF-1) in the pathophysiology of MPD was investigated by measuring circulating CSF-1 levels and examining their relationship to disease phenotype. Serum CSF-1...
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ورودعنوان ژورنال:
- Journal of clinical pathology
دوره 14 شماره
صفحات -
تاریخ انتشار 1961